Current Issue : October - December Volume : 2018 Issue Number : 4 Articles : 6 Articles
Objective. Acute pulmonary silicone embolism (APSE) related to subcutaneous silicone injections is a well-known entity. Recently,\na fewcases of pathologically confirmed chronic pulmonary silicone embolism (CPSE) frombreast implants have been reported.The\nprevalence of CPSE in women with breast augmentation is unknown. This study was done to determine the prevalence of CPSE in\nfemale lung transplant recipients with a history of breast augmentation and to determine whether breast augmentation plays a role\nin chronic lung diseases requiring lung transplantation. Methods. A retrospective chart review was performed to identify female\nlung transplant recipients with a history of breast augmentation prior to or at the time of lung transplantation. Ten patientsmeeting\nthese criteria were identified.The pathologic features of the explanted lungs of these patients were reexamined for CPSE by a boardcertified\npathologist with expertise in lung transplantation and pulmonary embolism. Results. Of 1518 lung transplant recipients at\nCleveland Clinic, 578 were females. Of 578 females, 10 (1.73%) had history of breast augmentation. A total of 84 H&E-stained slides\nfrom the explanted lungs from 10 cases were examined. No pathologic evidence of chronic silicone embolism was seen in any of\nthe 10 cases. Conclusions. CPSE is not associated with pulmonary disease leading to lung transplantation. Breast augmentation is\nnot a significant contributor to pulmonary disease requiring lung transplantation. Further studies are required to ascertain the\nprevalence of CPSE in the general breast augmentation populace and to define the relationship between breast augmentation and\npulmonary disease....
The incidence of thymic epithelial tumors (TETs) in the Chinese population was much higher than that in the North American\npopulation. In clinical treatment, the prognosis of benign tumors after surgical resection was significantly better than that of\nmalignant tumors. Currently, the commonly used clinical indicators for TET staging included Masaoka staging and WHO (2015)\npathological criteria; however, the distinction between the benign and malignant tumors and diagnosis is yet to be explored. The\ncurrent study demonstrated that the expression of PD-L1 in tumor cells was correlated with the degree of TET malignancy. The\nquantitative analysis of PD-L1 expression in 70 cases of TET tumor samples revealed that the positive rate of PD-L1 expression in\ntypes A, AB, B1, and B2 of thymoma (40 cases) was 37.5% (15/40), which was significantly lower than that in type B3 thymoma\nand thymic carcinoma (76.67%, 30 cases, 23/30) as demonstrated by chi-square test (...
The aim of this study was to investigate the characteristics of individuals with intraoral potentially malignant disorders (IOPMD)\nin an oral pathology service in Brazil. Cases were screened based on clinical diagnosis of leukoplakia (LKP), erythroleukoplakia\n(ELKP), and erythroplakia (EP). Clinical data and information regarding associated factors were gathered from biopsy reports.\nHistological diagnoseswere collected fromhistopathological records.Among 208 IOPMDcases, 84.13% involved LKP; 11.1%, ELKP;\nand 4.8%, EP.The most affected sites were the gingiva and buccal mucosa. Histologically, epithelial dysplasia was present in 66.8%\nof the lesions, acanthosis and hyperkeratosis without epithelial dysplasia were present in 27.9%, and squamous cell carcinoma was\npresent in 2.9%.Most patients were males, fair-skinned, withmean age of 53.4 years. Chronic smokers represented 73% of subjects,\nofwhich 30% also consumed alcohol. Smokers and drinkerswere mostly males (...
Background: Diagnosis of prostate cancer is certified by histology true prostate\nbiopsies. The aim of our study was to evaluate our prostate biopsy method.\nMaterial and Methods: It was a prospective study including patients\nunderwent prostate biopsy. Inclusion criteria were prostate specific antigen\n(PSA) level up to 4ng/ml and/or abnormal prostate at digital rectal examination.\nPatients who had risk factors of bleeding have been excluded of the\nstudy. The preparation before biopsy included antibioprophylaxy (Ciprofloxacine-\nTinidazole) and rectal hypertonic cleaning (Normacol*). Twelve cores\nhave been taken in each prostate by transrectal digital-guided way, using Biopty\nGun 18 Gauge. Local anesthesia has been done previously by intrarectal\napplication of 20 ml of gel of Lidoca�¯ne. Two other cores were taken into each\nabnormal area at rectal examination. The follow-up have been done during\ntwelve weeks. Results: Eighty patients of 65 years of age were included. Nine\npatients had familial history of prostate cancer. PSA levels ranged from 5 to\n6400 ng/ml with a median of 26.77 ng/ml �± 11.2. Complications occurred in\n11.25% of patients, principally infectious complications which caused death of\none patient by septicemia. The rate of cancer detection was 20%. Prostate abnormality\nat digital rectal examination and the presence of familial history of\nprostate cancer were not predictive factors of the presence of cancer on cores.\nConclusion: Our prostate biopsy method is limited by the lack of ultrasonographic\nguidance and is at important risk of infectious complications....
Context. Intravascular large B-cell lymphoma (IVLBCL) is a rare non-Hodgkin B-cell lymphoma with a poor prognosis. While\ntypically described as comprising large atypical cells restricted to the lumina of small blood vessels, it can showvariability in cell size.\nObjective. To report the clinicopathologic features of the IVLBCL with small cell morphology and discuss the practical implications\nof our findings. Design. We searched our archives for all IVLBCL diagnosed in our institution for the last 25 years (1992ââ?¬â??2017).\nSlides were reviewed independently by two hematopathologists. Results. We found a total of 11 cases of IVLBCL. Bone marrow,\nbrain, lymph node, pericardium, small bowel, and fallopian tube and ovary were the organs in which the lymphoma was initially\ndiagnosed. One of the cases initially diagnosed in the marrow showed intrasinusoidal involvement by a small cell lymphoma;\nthe diagnosis was confirmed by random skin biopsies showing intravascular large cells with the same phenotype. Retrospective\nreview of the liver on this case also showed the intrasinusoidal involvement by the disease consisting of small cells. In another\ncase, IVLBCL that was initially diagnosed in a small bowel biopsy was retrospectively found in a breast biopsy, but with small\ncell morphology. Conclusions. Our findings suggest that, in the presence of high clinical suspicion, IVLBCL should be high in the\ndifferential diagnosis when lymphoma is predominantly intravascular, even when the tumor cells are small. A timely diagnosis of\nthis entity can be critical. Hence, awareness of a small cell variant of IVLBCL should be increased....
Background.The diagnosis of Osteosarcoma (OSA) is not always straightforward. OSA may resembleOther Primary Bone Tumours\n(OPBT). The diagnosis of osteosarcoma is sometimes difficult especially in a very small specimen. Immunohistochemistry is one of\nancillary testing types that can help the diagnosis of many tumours. The aimof this study was to evaluate the validity of Osteocalcin\n(OCN) and Alkaline Phosphatase (ALP) immunohistochemistry in discriminating OSA from OPBT. Method.This study included\n50 selected human primary bone tumours, 25 cases of OSA and 25 cases of OPBT. Immunohistochemical evaluation of OCN and\nALP was done for all cases.The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and overall\naccuracy were calculated. Result. The mean age of OSA and OPBT patients was 19.6 �± 13.6 and 40.0 �± 16.3 years, respectively.\nOsteocalcin was positive in 17/25 (68%) cases of OSA and 16/25 (64%) cases of OPBT (...
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